Journal: Emerging Infectious Diseases
Article Title: Whole-Genome Analysis of Streptococcus pneumoniae Serotype 4 Causing Outbreak of Invasive Pneumococcal Disease, Alberta, Canada
doi: 10.3201/eid2707.204403
Figure Lengend Snippet: Maximum-likelihood core SNV unrooted phylogenetic tree of 190 Streptococcus pneumoniae serotype 4 isolates collected from patients in Alberta, Canada, 2010–2018. A total of 3,097 sites were used in the phylogeny, and 80.7% of the core genome was included. S. pneumoniae TIGR4 (arrow; National Center for Biotechnology Information accession number NC_003028.3) was used as a mapping reference. Cluster analysis did not group 1 ST205 isolate and TIGR4 with the other clade C strains. SNV, single nucleotide variant; ST, sequence type.
Article Snippet: Although another ST205 isolate from Edmonton and the TIGR4 reference strain (National Center for Biotechnology Information accession no. NC_003028.3) were proximal to clade C in the phylogenetic tree, ClusterPicker excluded them from the clade based on the clustering thresholds used.
Techniques: Variant Assay, Sequencing